Cat. No.: IBDA-431770
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Online InquiryTarget Information
| Target Name | SIGIRR |
| Uniprot ID | Q6IA17 |
| Cellular Localization | Membrane. |
| Immunogen | Synthetic peptide. |
| Function | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. |
Product Details
| Description | Rabbit monoclonal antibody to SIGIRR. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Rat, Human |
| Immunogen | Synthetic peptide. |
| Positive Control | IHC-P: Human kidney and colon tissue. Mouse kidney tissue. Rat kidney tissue WB: Hepa1-6 cell lysate. Mouse stomach, kidney, spleen and pancreas tissue lysate. Human stomach and fetal kidney lysate. Rat stomach and liver tissue lysate Flow Cyt (Intra): MEF and Hepa1-6 cells IP: Hepa1-6 whole cell lysate |
| Application | Flo, IHC-P, IP, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.2 Preservative: 0.01% Sodium Azide Constituent: PBS, 0.05% BSA, 40% Glycerol |
| Handling | Avoid freeze-thaw cycles. |