Cat. No.: IBDA-431768
Size:
Online InquiryTarget Information
| Target Name | SIGIRR |
| Uniprot ID | Q6IA17 |
| Cellular Localization | Membrane. |
| Immunogen | Recombinant fragment (His-tag) corresponding to Human SIGIRR aa 1-150. |
| Function | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. |
Product Details
| Description | Rabbit polyclonal antibody to SIGIRR. |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Immunogen affinity purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human, Pig |
| Immunogen | Recombinant fragment (His-tag) corresponding to Human SIGIRR aa 1-150. |
| Positive Control | IHC-P: Human breast cancer, liver, prostate and prostate cancer tissue. WB: Pig kidney lysate. Recombinant human SIGIRR protein. |
| Application | IHC-P, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: PBS, 50% Glycerol |
| Handling | Avoid freeze-thaw cycles. |