Simvastatin acid-d6 ammonium

Cat. No.: IBDI-435092

Simvastatin acid-d6 (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.

Product Details

Target	Endogenous Metabolite
Molecular Weight	459.65
Synonyms	Tenivastatin-d6 (ammonium
SMILES	O=C(C[[email protected]@H](C[[email protected]@H](CC[[email protected]@]1([H])[[email protected]](C=CC2=C[[email protected]@H](C[[email protected]@H]([[email protected]]12[H])OC(C(CC)(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C)C)O)O)[O-].[NH4+]

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.