SIRP Alpha Monoclonal Antibody

Target Information

Target Name	SIRP Alpha
Uniprot ID	P78324
Cellular Localization	Membrane.
Immunogen	Tissue, cells or virus corresponding to Pig SIRP alpha.
Function	Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Product Details

Description	FITC Mouse monoclonal antibody to SIRP alpha.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein G purified
Isotype	IgG1
Conjugation	FITC
Reactivity	Pig
Immunogen	Tissue, cells or virus corresponding to Pig SIRP alpha.
Application	Flo, IHC-Fr, IHC-P, IP, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.40 Preservative: 0.09% Sodium Azide Constituent: PBS, 1% BSA
Handling	Avoid freeze-thaw cycles.