SKLB0565

Cat. No.: IBDI-437032

SKLB0565 is a potent tubulin inhibitor. SKLB0565 shows significant anti-proliferative activity against CRC (colorectal carcinoma) cell lines, with IC50 values ranging from 0.012 μM to 0.081 μM. SKLB0565 causes G2/M phase arrest and mitochondria-mediated intrinsic apoptosis. SKLB0565 inhibits cell migration and disrupted the tube formation of HUVECs.

Product Details

Target	Microtubule/Tubulin | Apoptosis
Molecular Weight	400.91
SMILES	O=C1C(CNC2=C3N=CN(C4CCCC4)C3=NC(Cl)=N2)=C(CC)C=C(CC)N1

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.