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(S,R,S)-AHPC hydrochloride

Cat. No.: IBDI-434895

(S,R,S)-AHPC (VH032-NH2) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

Size (Solid):

Product Details

Target Ligands for E3 Ligase
Molecular Weight 467.02
Appearance Solid
Synonyms VH032-NH2 hydrochloride, VHL ligand 1 hydrochloride
SMILES O=C([[email protected]](C[[email protected]@H](O)C1)N1C([[email protected]@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl
Purity 99.54%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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