(S,R,S)-AHPC-Me dihydrochloride

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(S,R,S)-AHPC-Me dihydrochloride

Cat. No.: IBDI-434307

(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	Ligands for E3 Ligase
Molecular Weight	517.51
Appearance	Solid
Synonyms	VHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride
SMILES	N[[email protected]@H](C(C)(C)C)C(N1[[email protected]](C(N[[email protected]@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[[email protected]@H](O)C1)=O.Cl.Cl
Purity	99.54%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.