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(S,R,S)-AHPC-Me hydrochloride

Cat. No.: IBDI-434306

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

Size (Solid):

Product Details

Target Ligands for E3 Ligase
Molecular Weight 481.05
Appearance Solid
Synonyms VHL ligand 2 hydrochloride, E3 ligase Ligand 1
SMILES N[[email protected]@H](C(C)(C)C)C(N1[[email protected]](C(N[[email protected]@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[[email protected]@H](O)C1)=O.Cl
Purity 99.59%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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