(S,R,S)-AHPC TFA

Cat. No.: IBDI-434037

(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

Product Details

Target	Ligands for E3 Ligase
Molecular Weight	544.59
Synonyms	VH032-NH2 TFA, VHL ligand 1 TFA
SMILES	FC(F)(F)C(O)=O.O=C([[email protected]](C[[email protected]@H](O)C1)N1C([[email protected]@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.