Taccalonolide A

Cat. No.: IBDI-430985

Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.

Product Details

Target	Microtubule/Tubulin | Apoptosis
Molecular Weight	702.74
Appearance	Solid
SMILES	C[[email protected]@]12[[email protected]]([[email protected]@H](OC(C)=O)[[email protected]]3([H])[[email protected]]2([H])[[email protected]@H](C=C(O4)[[email protected]@]3([[email protected]](O)(C4=O)C)C)C)([H])[[email protected]@]([[email protected]]5O)([H])[[email protected]]([[email protected]]6([[email protected]]([[email protected]@H](O7)[[email protected]@H]7C[[email protected]]6([H])C5=O)OC(C)=O)C)([H])[[email protected]](OC(C)=O)[[email protected]@H]1OC(C)=O
Structure Classification	Steroids
Purity	99.29%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.