Talotrexin

Cat. No.: IBDI-434530

Talotrexin (PT523), an analog of Aminopterin (HY-14518), is a nonpolyglutamatable classic antifolate. Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth.

Product Details

Target	Antifolate | Dihydrofolate reductase (DHFR)
Molecular Weight	573.56
Synonyms	PT523
SMILES	NC1=NC(N)=NC2=C1N=C(CNC3=CC=C(C=C3)C(N[[email protected]](C(O)=O)CCCNC(C4=C(C=CC=C4)C(O)=O)=O)=O)C=N2

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.