Thailanstatin A

Cat. No.: IBDI-436623

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC.

Product Details

Target	ADC Cytotoxin
Molecular Weight	535.63
Appearance	Solid
SMILES	O=C(O)C[[email protected]@H](O[[email protected]](/C=C/C(C)=C/C[[email protected]]1[[email protected]@H](C)C[[email protected]@H](NC(/C=C\[[email protected]@H](OC(C)=O)C)=O)[[email protected]@H](C)O1)[[email protected]]2O)C[[email protected]]32CO3
Purity	98.00%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.