Cat. No.: IBDA-431948
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Online InquiryTarget Information
| Target Name | THOC5 |
| Uniprot ID | Q13769 |
| Cellular Localization | Nucleus. Cytoplasm. Shuttles between nucleus and cytoplasm. |
| Immunogen | Synthetic peptide within Human THOC5 aa 650-750. |
| Function | Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and ALYREF/THOC4. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. |
Product Details
| Description | Rabbit monoclonal antibody to THOC5. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Human |
| Immunogen | Synthetic peptide within Human THOC5 aa 650-750. |
| Positive Control | 293T, HeLa, NIH 3T3 and A549 cell lysates |
| Application | WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at -20 °C |
| Storage Buffer | pH: 7.20 Preservative: 0.05% Sodium Azide Constituent: 40% Glycerol, 9.85% Tris Glycine, 50% Tissue Culture Supernatant |
| Handling | Avoid freeze-thaw cycles. |