THOC5 Monoclonal Antibody

Target Information

Target Name	THOC5
Uniprot ID	Q13769
Cellular Localization	Nucleus. Cytoplasm. Shuttles between nucleus and cytoplasm.
Immunogen	Synthetic peptide.
Function	Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and ALYREF/THOC4. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.

Product Details

Description	Rabbit monoclonal antibody to THOC5.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Tissue culture supernatant
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Rat, Human
Immunogen	Synthetic peptide.
Positive Control	293T and HeLa cell lysates. 293T cells
Application	Flo, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20 °C
Storage Buffer	pH: 7.2 Preservative: 0.01% Sodium Azide Constituent: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue Culture Supernatant
Handling	Avoid freeze-thaw cycles.