TLR2 Monoclonal Antibody

Target Information

Target Name	TLR2
Uniprot ID	O60603
Cellular Localization	Membrane.
Immunogen	Recombinant human TLR2 produced by the CHO/CD14 reporter cell line.
Function	Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

Product Details

Description	Mouse monoclonal antibody to TLR2.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein G purified
Isotype	IgG2a
Conjugation	Unconjugated
Reactivity	Dog, Human, Cynomolgus monkey, Rhesus monkey, Common marmoset
Immunogen	Recombinant human TLR2 produced by the CHO/CD14 reporter cell line.
Positive Control	WB: THP1 + LPS. IHC-P: Human TLR2. ICC: Human U937 cells. Flow: Human peripheral blood mononuclear cells.
Application	Flo, FuncS, ICC/IF, IP, Neut, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C
Storage Buffer	Constituent: PBS, 1% BSA
Handling	Avoid freeze-thaw cycles.