Cat. No.: IBDA-435234
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Online InquiryTarget Information
| Target Name | TLR3 |
| Uniprot ID | O15455 |
| Cellular Localization | Endoplasmic reticulum membrane. Endosome membrane. |
| Immunogen | Recombinant fragment. |
| Function | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. |
Product Details
| Description | Rabbit monoclonal antibody to TLR3. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Human |
| Immunogen | Recombinant fragment. |
| Positive Control | WB: poly(I:C) transfected J774A.1, HT-29 and HCT116 whole cell lysate. Human tonsil tissue. Mouse spleen tissue. |
| Application | WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.2 Preservative: 0.01% Sodium Azide Constituent: 40% Glycerol, 0.05% BSA, 59% PBS |
| Handling | Avoid freeze-thaw cycles. |