TLR3 Monoclonal Antibody

Target Information

Target Name	TLR3
Uniprot ID	O15455
Cellular Localization	Endoplasmic reticulum membrane. Endosome membrane.
Immunogen	Recombinant full length protein (DDDDK-tag) corresponding to Human TLR3.
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Product Details

Description	Mouse monoclonal antibody to TLR3.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein G purified
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant full length protein (DDDDK-tag) corresponding to Human TLR3.
Positive Control	Placenta and pancreas. Monocyte-derived immature dendritic cells (see paper by Matsumoto et al,2003). Monocytes, granulocytes, lymphocytes, human fibroblast, MRC-5 & FS-4 cells Flow Cyt (Intra):THP-1 cells.
Application	Flo

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C
Storage Buffer	Constituent: PBS, 0.1% BSA
Handling	Avoid freeze-thaw cycles.