Cat. No.: IBDA-435238
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Online InquiryTarget Information
| Target Name | TLR3 |
| Uniprot ID | O15455 |
| Cellular Localization | Endoplasmic reticulum membrane. Endosome membrane. |
| Immunogen | Synthetic peptide corresponding to Human TLR3 aa 55-70 conjugated to keyhole limpet haemocyanin. |
| Function | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. |
Product Details
| Description | Mouse monoclonal antibody to TLR3. |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Purity | Protein G purified |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Human |
| Immunogen | Synthetic peptide corresponding to Human TLR3 aa 55-70 conjugated to keyhole limpet haemocyanin. |
| Positive Control | Human intestine tissue lysate, mouse spleen Flow Cyt (Intra): human B cells, human monocytes, SW480, SW620 (colon cancer) |
| Application | Flo, IHC-P, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.4 Preservative: 0.05% Sodium Azide Constituent: PBS, 0.05% BSA |
| Handling | Avoid freeze-thaw cycles. |