TLR3 Polyclonal Antibody

Target Information

Target Name	TLR3
Uniprot ID	O15455
Cellular Localization	Endoplasmic reticulum membrane. Endosome membrane.
Immunogen	Recombinant fragment, corresponding to a region within amino acids 464-647 of Human TLR3.
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Product Details

Description	Rabbit polyclonal antibody to TLR3.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Rat, Human
Immunogen	Recombinant fragment, corresponding to a region within amino acids 464-647 of Human TLR3.
Positive Control	WB: K562 and THP-1 whole cell lysates. IHC-P: Human TOV-112D xenograft, mouse liver, rat pancreas tissue. IF: HeLa cells.
Application	ICC/IF, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	pH: 7 Preservative: 0.025% Proclin 300 Constituent: 79% PBS, 20% Glycerol
Handling	Avoid freeze-thaw cycles.