TLR4 Monoclonal Antibody

Target Information

Target Name	TLR4
Uniprot ID	O00206
Cellular Localization	Membrane.
Immunogen	Synthetic peptide corresponding to Human TLR4 aa 100-200 conjugated to Keyhole Limpet Haemocyanin (KLH).
Function	Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.

Product Details

Description	Mouse monoclonal antibody to TLR4.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein G purified
Isotype	IgG2b
Conjugation	Unconjugated
Reactivity	Mouse, Rat, Human, Pig
Immunogen	Synthetic peptide corresponding to Human TLR4 aa 100-200 conjugated to Keyhole Limpet Haemocyanin (KLH).
Positive Control	Human, Mouse and Rat small intestine for Western Blot or THP1 cells for FACS analysis. Flow Cyt (Intra): Jurkat cells.
Application	ELISA, Flo, ICC, ICC/IF, IHC-Fr, IHC-P

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.40 Preservative: 0.05% Sodium Azide Constituent: 99% PBS, 0.05% BSA
Handling	Avoid freeze-thaw cycles.