Cat. No.: IBDA-435336
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Online InquiryTarget Information
| Target Name | TLR4 |
| Uniprot ID | O00206 |
| Cellular Localization | Membrane. |
| Immunogen | Full length native protein (purified) corresponding to Mouse TLR4. |
| Function | Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific. |
Product Details
| Description | PE Rat monoclonal antibody to TLR4. |
| Host Species | Rat |
| Clonality | Monoclonal |
| Purity | Protein G purified |
| Isotype | IgG2a |
| Conjugation | PE |
| Reactivity | Mouse |
| Immunogen | Full length native protein (purified) corresponding to Mouse TLR4. |
| Positive Control | 3-day thioglycolate-induced BALB/c macrophages. mouse peritoneal exudate cells |
| Application | Flo |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at 4 °C |
| Storage Buffer | pH: 7.20 Preservative: 0.09% Sodium Azide Constituent: 0.87% Sodium Chloride, PBS |