TLR4 Monoclonal Antibody

Target Information

Target Name	TLR4
Uniprot ID	O00206
Cellular Localization	Membrane.
Immunogen	Tissue, cells or virus corresponding to TLR4.
Function	Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.

Product Details

Description	Mouse monoclonal antibody to TLR4 - Low Endotoxin, Azide Free.
Host Species	Mouse
Clonality	Monoclonal
Purity	Immunogen affinity purified
Isotype	IgG2a
Conjugation	Unconjugated
Reactivity	Rat, Human
Immunogen	Tissue, cells or virus corresponding to TLR4.
Application	Flo, ICC

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	Constituent: PBS
Handling	Avoid freeze-thaw cycles.