Cat. No.: IBDA-435340
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Online InquiryTarget Information
| Target Name | TLR4 |
| Uniprot ID | O00206 |
| Cellular Localization | Membrane. |
| Immunogen | Synthetic peptide within Human TLR4 aa 150-250 conjugated to keyhole limpet haemocyanin. |
| Function | Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific. |
Product Details
| Description | Rabbit polyclonal antibody to TLR4. |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Rat |
| Immunogen | Synthetic peptide within Human TLR4 aa 150-250 conjugated to keyhole limpet haemocyanin. |
| Positive Control | WB: Rat H9C2 cell lysates. |
| Application | WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.2 Preservative: 0.09% Sodium Azide Constituent: 1% BSA, 50% Glycerol |
| Handling | Avoid freeze-thaw cycles. |