TLR7 Monoclonal Antibody

Target Information

Target Name	TLR7
Uniprot ID	Q9NYK1
Cellular Localization	Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Immunogen	Synthetic peptide within Human TLR7 aa 1000 to the C-terminus (C terminal).
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Product Details

Description	Rabbit monoclonal antibody to TLR7.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide within Human TLR7 aa 1000 to the C-terminus (C terminal).
Positive Control	WB: Raji, Daudi and Ramos cell lysates. IHC-P: Human tonsil tissue.
Application	IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.2 Preservative: 0.01% Sodium Azide Constituent: 40% Glycerol, 0.05% BSA, 59% PBS
Handling	Avoid freeze-thaw cycles.