TLR9 Monoclonal Antibody

Target Information

Target Name	TLR9
Uniprot ID	Q9NR96
Cellular Localization	Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Immunogen	Synthetic peptide corresponding to Human TLR9 aa 268-284 conjugated to keyhole limpet haemocyanin.
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Product Details

Description	Mouse monoclonal antibody to TLR9.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein G purified
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Mouse, Rat, Human
Immunogen	Synthetic peptide corresponding to Human TLR9 aa 268-284 conjugated to keyhole limpet haemocyanin.
Positive Control	WB: Human peripheral blood mononuclear cells (PBMCs). Human, mouse and rat intestine tissue lysates. Flow Cyt (Intra): Ramos and PBMC cells. IHC-P: Human spleen tissue. ICC/IF: A549 cells.
Application	Flo, ICC/IF, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.40 Preservative: 0.05% Sodium Azide Constituent: 0.05% BSA, PBS
Handling	Avoid freeze-thaw cycles.