TLR9 Monoclonal Antibody

Target Information

Target Name	TLR9
Uniprot ID	Q9NR96
Cellular Localization	Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Immunogen	Recombinant fragment within TLR9.
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Product Details

Description	Biotin Mouse monoclonal antibody to TLR9.
Host Species	Mouse
Clonality	Monoclonal
Isotype	IgG2a
Conjugation	Biotin
Reactivity	Mouse, Dog, Human
Immunogen	Recombinant fragment within TLR9.
Positive Control	RAW macrophages and TLR9 transfected HEK293 cells. RAW264.7 macrophages stimulated with IFN gamma.
Application	Flo, ICC/IF, IHC-Fr, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	Preservative: 0.02% Sodium Azide Constituent: PBS, 0.1% BSA
Handling	Avoid freeze-thaw cycles.