Cat. No.: IBDA-431395
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Online InquiryTarget Information
| Target Name | TLR9 |
| Uniprot ID | Q9NR96 |
| Cellular Localization | Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. |
| Immunogen | Recombinant fragment corresponding to Mouse TLR9 aa 600-900. |
| Function | Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. |
Product Details
| Description | Rat monoclonal antibody to TLR9. |
| Host Species | Rat |
| Clonality | Monoclonal |
| Purity | Protein G purified |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Reactivity | Mouse |
| Immunogen | Recombinant fragment corresponding to Mouse TLR9 aa 600-900. |
| Positive Control | Mouse small intestine lysate. Mouse splenocytes. |
| Application | Flo, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | Preservative: 0.05% Sodium Azide Constituent: 99% PBS, 0.05% BSA |
| Handling | Avoid freeze-thaw cycles. |