TLR9 Polyclonal Antibody

Target Information

Target Name	TLR9
Uniprot ID	Q9NR96
Cellular Localization	Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Immunogen	31 amino acid (aa) synthetic peptide, corresponding to aa 205-235 of the N-terminal domain of Human TLR9.
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Product Details

Description	Goat polyclonal antibody to TLR9 - Aminoterminal end.
Host Species	Goat
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Human
Immunogen	31 amino acid (aa) synthetic peptide, corresponding to aa 205-235 of the N-terminal domain of Human TLR9.
Application	IHC-P

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	pH: 7.20 Preservative: 0.1% Sodium Azide Constituent: 0.1% BSA, 0.21% Potassium Phosphate, 0.812% Sodium Chloride
Handling	Avoid freeze-thaw cycles.