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Toyocamycin

Cat. No.: IBDI-431462

Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1α-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC50 value of 80 nM with affecting IRE1α auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC50 value of 79 nM.

Size (Solid):

Product Details

Target IRE1 | Fungal | Antibiotic | Apoptosis | CDK
Molecular Weight 291.26
Appearance Solid
Synonyms Vengicide
SMILES O[[email protected]]1[[email protected]@H](O[[email protected]](CO)[[email protected]]1O)N2C3=C(C(N)=NC=N3)C(C#N)=C2
Purity 99.90%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Powder: -20°C/3 years
In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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