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Trabectedin

Cat. No.: IBDI-430097

Trabectedin (Ecteinascidin 743; ET-743) is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has the potential for soft tissue sarcoma and ovarian cancer research.

Size (Solid):

Product Details

Target Reactive Oxygen Species | Apoptosis
Molecular Weight 761.84
Appearance Solid
Synonyms Ecteinascidin 743, ET-743
SMILES CC1=C(OCO2)C2=C([[email protected]](COC3=O)N4[[email protected]]([[email protected]@H]5SC[[email protected]]63C(C=C(OC)C(O)=C7)=C7CCN6)([H])[[email protected]@H]8N(C)[[email protected]@H](CC9=CC(C)=C(OC)C(O)=C98)[[email protected]@H]4O)C5=C1OC(C)=O
Structure Classification Alkaloids>Isoquinoline Alkaloids
Purity 99.86%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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