TRAF6 Monoclonal Antibody

Target Information

Target Name	TRAF6
Uniprot ID	Q9Y4K3
Cellular Localization	Cytoplasm. Cytoplasm > cell cortex. Nucleus. Found in the nuclei of some agressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T-and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus.
Immunogen	Synthetic peptide.
Function	E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor.

Product Details

Description	Rabbit monoclonal antibody to TRAF6.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Alexa Fluor® 647
Reactivity	Human
Immunogen	Synthetic peptide.
Positive Control	ICC/IF: HeLa cells Flow Cyt (Intra): HAP1-wt cells
Application	Flo, ICC/IF

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C. Store in the dark
Storage Buffer	pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: 1% BSA, 30% Glycerol, PBS
Handling	Avoid freeze-thaw cycles.