TRAF6 Polyclonal Antibody

Target Information

Target Name	TRAF6
Uniprot ID	Q9Y4K3
Cellular Localization	Cytoplasm. Cytoplasm > cell cortex. Nucleus. Found in the nuclei of some agressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T-and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus.
Immunogen	Recombinant fragment corresponding to a region within amino acids 144-408 of Human TRAF6 .
Function	E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor.

Product Details

Description	Rabbit polyclonal antibody to TRAF6.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Rat, Human
Immunogen	Recombinant fragment corresponding to a region within amino acids 144-408 of Human TRAF6 .
Positive Control	WB: A431, A549, HeLa, HepG2,NIH/3T3, BCL-1, PC-12, Rat2 cell lysate. IHC-P: 59T xenograft, mouse lung and rat brain tissue. IF: HeLa cells. IP: K562 whole cell lysate.
Application	ICC/IF, IHC-P, IP, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7 Preservative: 0.025% Proclin 300 Constituent: 78% PBS, 1% BSA, 20% Glycerol
Handling	Avoid freeze-thaw cycles.