Cat. No.: IBDA-434890
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Online InquiryTarget Information
| Target Name | Transferrin Receptor |
| Uniprot ID | P02786 |
| Cellular Localization | Secreted and Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Immunogen | Recombinant fragment within Human Transferrin Receptor aa 94-212 (extracellular). |
| Function | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. |
Product Details
| Description | Mouse monoclonal antibody to Transferrin Receptor - BSA and Azide Free. |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG2b |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Recombinant fragment within Human Transferrin Receptor aa 94-212 (extracellular). |
| Positive Control | Jurkat, HeLa, MCF-7 or K562 cells. Human placenta, bone marrow and breast carcinoma tissues. |
| Application | IHC-P |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.2 Constituent: PBS |
| Handling | Avoid freeze-thaw cycles. |