Transferrin Receptor Monoclonal Antibody

Target Information

Target Name	Transferrin Receptor
Uniprot ID	P02786
Cellular Localization	Secreted and Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Immunogen	Recombinant fragment within Human Transferrin Receptor aa 94-212 (extracellular).
Function	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.

Product Details

Description	Mouse monoclonal antibody to Transferrin Receptor.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein A/G purified
Isotype	IgG2b
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant fragment within Human Transferrin Receptor aa 94-212 (extracellular).
Positive Control	IHC-P: Human placenta tissue.
Application	IHC-P, Protein Array

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.2 Preservative: 0.05% Sodium Azide Constituent: PBS, 0.05% BSA
Handling	Avoid freeze-thaw cycles.