Transferrin Receptor Monoclonal Antibody

Target Information

Target Name	Transferrin Receptor
Uniprot ID	P02786
Cellular Localization	Secreted and Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Immunogen	Pre-B cell line NALM-6 (Human).
Function	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.

Product Details

Description	PE Mouse monoclonal antibody to Transferrin Receptor.
Host Species	Mouse
Clonality	Monoclonal
Isotype	IgG1
Conjugation	PE
Reactivity	Human
Immunogen	Pre-B cell line NALM-6 (Human).
Positive Control	Human blood cells.
Application	Flo

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at 4 °C
Storage Buffer	pH: 7.40 Preservative: 0.097% Sodium Azide Constituent: PBS, BSA