Tristetraprolin/TTP Monoclonal Antibody - BSA and Azide Free

Target Information

Target Name	Tristetraprolin/TTP
Uniprot ID	P26651
Cellular Localization	Nucleus. Cytoplasm. Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
Immunogen	Recombinant full length protein corresponding to Human Tristetraprolin/TTP aa 1-350.
Function	mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).

Product Details

Description	Mouse monoclonal antibody to Tristetraprolin/TTP - BSA and Azide Free.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein A/G purified
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Mouse, Dog, Human, African green monkey
Immunogen	Recombinant full length protein corresponding to Human Tristetraprolin/TTP aa 1-350.
Positive Control	WB: HeLa, SVT2, A549, COS7, Jurkat, MDCK and MCF7 cells lysate. IHC-P: Human colon, colon adenocarcinoma, ovary, endometrium, prostate tissue. IF: COS7 cell lysate. Flow Cyt (Intra): HEK-293T transfected with Tristetraprolin
Application	Flo, ICC/IF, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.3 Constituent: PBS
Handling	Avoid freeze-thaw cycles.