Tristetraprolin/TTP Monoclonal Antibody

Target Information

Target Name	Tristetraprolin/TTP
Uniprot ID	P26651
Cellular Localization	Nucleus. Cytoplasm. Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
Immunogen	Recombinant full length protein corresponding to Human Tristetraprolin/TTP aa 1 to the C-terminus.
Function	mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).

Product Details

Description	Mouse monoclonal antibody to Tristetraprolin/TTP.
Host Species	Mouse
Clonality	Monoclonal
Purity	Affinity purified
Isotype	IgG2a
Conjugation	Unconjugated
Reactivity	Mouse, Dog, Human
Immunogen	Recombinant full length protein corresponding to Human Tristetraprolin/TTP aa 1 to the C-terminus.
Positive Control	WB: SVT2, A549 and MDCK cell extracts. Mouse liver extract. HEK-293T cell lysate transfected with pCMV6-ENTRY Tristetraprolin/TTP cDNA. Flow Cyt (Intra): HeLa and Jurkat cells. IHC-P: Human breast, lung carcinoma, pancreas carcinoma, endometrium, endometrium adenocarcinoma, bladder carcinoma and tonsil tissues.
Application	Flo, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.30 Preservative: 0.02% Sodium Azide Constituent: PBS, 50% Glycerol, 1% BSA
Handling	Avoid freeze-thaw cycles.