Tristetraprolin/TTP Monoclonal Antibody

Target Information

Target Name	Tristetraprolin/TTP
Uniprot ID	P26651
Cellular Localization	Nucleus. Cytoplasm. Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
Immunogen	Recombinant full length protein corresponding to Human Tristetraprolin/TTP.
Function	mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).

Product Details

Description	Mouse monoclonal antibody to Tristetraprolin/TTP.
Host Species	Mouse
Clonality	Monoclonal
Purity	Protein G purified
Isotype	IgG1
Conjugation	Unconjugated
Reactivity	Human, African green monkey
Immunogen	Recombinant full length protein corresponding to Human Tristetraprolin/TTP.
Positive Control	HEK293T cells transfected with pCMV6-ENTRY Tristetraprolin/TTP cDNA. Human colon, colon adenocarcinoma, ovary, endometrium and prostate tissues. COS7 cells transiently transfected by pCMV6-ENTRY Tristetraprolin/TTP.
Application	Flo, ICC/IF, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C
Storage Buffer	pH: 7.30 Preservative: 0.02% Sodium Azide Constituent: 48% PBS, 1% BSA, 50% Glycerol
Handling	Avoid freeze-thaw cycles.