Tristetraprolin/TTP Polyclonal Antibody

Target Information

Target Name	Tristetraprolin/TTP
Uniprot ID	P26651
Cellular Localization	Nucleus. Cytoplasm. Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
Immunogen	Synthetic peptide within Human Tristetraprolin/TTP aa 50-150 conjugated to keyhole limpet haemocyanin.
Function	mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).

Product Details

Description	Rabbit polyclonal antibody to Tristetraprolin/TTP.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide within Human Tristetraprolin/TTP aa 50-150 conjugated to keyhole limpet haemocyanin.
Positive Control	This antibody gave a positive signal in the following whole cell lysates: HeLa. HepG2. Jurkat. Ramos. A431. SK N SH. PC3.
Application	WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: PBS
Handling	Avoid freeze-thaw cycles.