Trovafloxacin

Cat. No.: IBDI-435556

Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1.

Product Details

Target	Bacterial | TopoisomeRase | Antibiotic
Molecular Weight	416.35
Appearance	Solid
SMILES	O=C(C1=CN(C2=CC=C(F)C=C2F)C3=NC(N4C[[email protected]@]5([H])[[email protected]](N)[[email protected]@]5([H])C4)=C(F)C=C3C1=O)O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.