Tubulysin

Cat. No.: IBDI-436589

Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule agent conjugate (SMDC) delivery system.

Product Details

Target	Microtubule/Tubulin
Molecular Weight	842.10
SMILES	O=C(O)[[email protected]@H](C)C[[email protected]@H](NC(C1=CSC([[email protected]](OC(C)=O)C[[email protected]@H](N(COC(CC(C)C)=O)C([[email protected]@H](NC([[email protected]@H]2N(C)CCCC2)=O)[[email protected]@H](C)CC)=O)C(C)C)=N1)=O)CC3=CC=C(C)C=C3

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.