Ube2N/Ubc13 Monoclonal Antibody

Target Information

Target Name	Ube2N/Ubc13
Uniprot ID	P61088
Cellular Localization	Nucleus. Cytoplasm.
Immunogen	Synthetic peptide.
Function	The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD.

Product Details

Description	Rabbit monoclonal antibody to Ube2N / Ubc13.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide.
Positive Control	WB: Jurkat, HeLa, Raji and 293T cell lysates Flow Cyt (Intra): Jurkat cells
Application	Flo, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue Culture Supernatant
Handling	Avoid freeze-thaw cycles.