Ube2N/Ubc13 Polyclonal Antibody

Target Information

Target Name	Ube2N/Ubc13
Uniprot ID	P61088
Cellular Localization	Nucleus. Cytoplasm.
Immunogen	Synthetic peptide corresponding to Human Ube2N/ Ubc13 aa 1-100 conjugated to keyhole limpet haemocyanin.
Function	The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD.

Product Details

Description	Rabbit polyclonal antibody to Ube2N / Ubc13.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Rat, Human
Immunogen	Synthetic peptide corresponding to Human Ube2N/ Ubc13 aa 1-100 conjugated to keyhole limpet haemocyanin.
Positive Control	This antibody gave a positive signal in Human Small Intestine, Mouse Testis and Rat Testis tissue lysates, and the following whole cell lysates: HeLa. HeLa Nuclear. HEK293. U20S. Jurkat. NIH3T3. PC12.
Application	WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: PBS
Handling	Avoid freeze-thaw cycles.