ULBP1 Monoclonal Antibody

Target Information

Target Name	ULBP1
Uniprot ID	Q9BZM6
Cellular Localization	Cell membrane. Endoplasmic reticulum. Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
Immunogen	Synthetic peptide within Human ULBP1 aa 1-100.
Function	Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Product Details

Description	Rabbit monoclonal antibody to ULBP1.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human, Recombinant fragment
Immunogen	Synthetic peptide within Human ULBP1 aa 1-100.
Positive Control	Lysate from CHO cells transfected with ULBP1. HeLa, K562 and 293T cell lysates. K562 cells.
Application	Flo, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.01% Sodium Azide Constituent: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue Culture Supernatant
Handling	Avoid freeze-thaw cycles.