ULBP1 Polyclonal Antibody

Target Information

Target Name	ULBP1
Uniprot ID	Q9BZM6
Cellular Localization	Cell membrane. Endoplasmic reticulum. Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
Immunogen	Recombinant fragment corresponding to Human ULBP1 aa 150 to the C-terminus.
Function	Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Product Details

Description	Rabbit polyclonal antibody to ULBP1.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Recombinant fragment corresponding to Human ULBP1 aa 150 to the C-terminus.
Positive Control	ICC/IF: SiHa cells.
Application	ICC/IF

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.20 Preservative: 0.02% Sodium Azide Constituent: 40% Glycerol, PBS
Handling	Avoid freeze-thaw cycles.