Cat. No.: IBDA-431480
Size:
Online InquiryTarget Information
| Target Name | ULBP2+ULBP5+ULBP6 |
| Uniprot ID | Q9BZM5 |
| Cellular Localization | Cell membrane. Secreted. |
| Immunogen | Recombinant fragment. |
| Function | Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. |
Product Details
| Description | Rabbit monoclonal antibody to ULBP2 - BSA and Azide Free. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Recombinant fragment. |
| Positive Control | Flow Cyt (Intra): BxPC-3 (Human pancreas adenocarcinoma epithelial cells). HEK-293T (Human embryonic kidney epithelial cell) transfected with a human ULBP2 expression vector. Flow Cyt: BxPC-3 cells |
| Application | Flo, Flo |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Store at 4 °C |
| Storage Buffer | pH: 7.20 Constituent: 100% PBS |