Verrucarin A

Cat. No.: IBDI-432292

Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53.

Product Details

Target	Apoptosis | Reactive Oxygen Species
Molecular Weight	502.55
Appearance	Solid
Synonyms	Muconomycin A
SMILES	C[[email protected]@]12[[email protected]]3(CO3)[[email protected]@]4([H])C[[email protected]@]1([H])OC(/C=C/C=C/C(OCC[[email protected]@H](C)[[email protected]](O)C(OC[[email protected]]25[[email protected]](C=C(C)CC5)([H])O4)=O)=O)=O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.