VHL Ligand 8

Cat. No.: IBDI-437873

VHL Ligand 8 is a VHL ligand. VHL Ligand 8 can be used to synthesize ARD-266 (HY-133020), a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM.

Product Details

Target	Ligands for E3 Ligase
Molecular Weight	443.49
Appearance	Solid
SMILES	OC(C[[email protected]@H](C1=CC=CC=C1)NC([[email protected]]2N(C([[email protected]](C(C)C)C3=CC(C)=NO3)=O)C[[email protected]](O)C2)=O)=O
Purity	98.12%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.