VU0424465

Cat. No.: IBDI-435964

VU0424465 is a potent and partial PAM (positive allosteric modulator)-agonist for mGlu5 mediated iCa 2+ mobilization. VU0424465 exhibits high affinity at MPEP allosteric binding site, with a Ki value of 11.8 nM. VU0424465 is also a agonist for pERK1/2 in cortical neurons.

Product Details

Target	mGluR | PERK
Molecular Weight	326.36
SMILES	O=C(N[[email protected]](C)C(O)(C)C)C1=NC=C(C=C1)C#CC2=CC=CC(F)=C2

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.