Xestospongin C

Cat. No.: IBDI-430121

Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca 2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca 2+ signaling in neuronal and nonneuronal cells.

Product Details

Target	Calcium Channel | Apoptosis
Molecular Weight	446.71
Appearance	Solid
Synonyms	(-)-Xestospongin C
SMILES	[H][[email protected]]1([[email protected]](CCCCCC[[email protected]@](CCN2CCC3)([H])O[[email protected]@]2([H])[[email protected]]3([H])CCCCCC4)([H])CCC5)N5CC[[email protected]]4([H])O1
Structure Classification	Alkaloids>Piperidine Alkaloids
Purity	≥90.0%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.